Review
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Ursodeoxycholic acid in pregnancy cholestasis: symptom and biochemical improvement in 73.3%
What it means for practice
The authors support ursodeoxycholic acid for control of pruritus and biochemical abnormalities. They emphasize early diagnosis, monitoring, and timely delivery in intrahepatic cholestasis of pregnancy.
Summary
A prospective observational study in Eastern India evaluated the response to ursodeoxycholic acid in 60 pregnant women with intrahepatic cholestasis of pregnancy. The study addressed symptom control, changes in biochemical parameters, and maternal and fetal pregnancy outcomes.
According to the abstract, significant improvement in pruritus and biochemical parameters was observed in 73.3% of patients receiving ursodeoxycholic acid. The abstract does not report the magnitude of changes in individual parameters, response criteria, or statistical estimates.
Elevated serum bile acid levels were strongly associated with adverse pregnancy outcomes, including preterm delivery and cesarean sections. Specific bile acid thresholds and the frequencies of these outcomes are not provided in the abstract.
The authors emphasize early diagnosis, monitoring, and timely delivery to improve maternal and fetal outcomes. Their conclusion regarding ursodeoxycholic acid concerns its effectiveness in controlling symptoms and biochemical abnormalities. The abstract provides no separate data on the effect of treatment on the frequency of adverse pregnancy outcomes.
Source
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Fetomaternal Outcomes and Response to Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study from Eastern India.
Reviewed by: DrugCard editorial team ·
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