Case
Published · Updated · 2 min read
Omeprazole and pityriasis rosea-like subacute cutaneous lupus erythematosus
What it means for practice
When assessing a pityriasis rosea-like eruption after omeprazole initiation, consider drug-induced subacute cutaneous lupus erythematosus.
Summary
The report describes a case of subacute cutaneous lupus erythematosus with pityriasis rosea-like features that the authors attribute to omeprazole. The condition developed after initiation of this proton pump inhibitor. The main signal is the possibility of this form of drug-induced skin disease during omeprazole treatment.
According to the abstract, the publication addresses the clinical presentation, diagnosis, and temporal relationship between drug administration and symptom onset. However, the abstract itself provides no description of individual skin lesions, diagnostic test results, or the exact interval to reaction onset. The patient’s age and sex, omeprazole dose, and duration of treatment are also not reported.
The authors emphasize the importance of recognizing drug-induced lupus erythematosus, particularly with omeprazole, and carefully monitoring patients receiving this medication.
The available description does not report the course after withdrawal, rechallenge, or assessment of alternative causes. The reported temporal relationship alone therefore does not establish causality with confidence.
Case analysis
- Likely mechanism
- General pharmacological explanation, not provided in the abstract: drug-induced cutaneous lupus erythematosus involves an autoimmune reaction. The specific mechanism of the reaction to omeprazole in this case is not described.
- Causality assessment
- Provisional editorial WHO-UMC assessment: possible. The condition reportedly developed after omeprazole initiation, but the exact latency, course after withdrawal, rechallenge, and alternative causes are not reported. The abstract provides no author-reported causality assessment.
- Take-home lesson
- A pityriasis rosea-like eruption after omeprazole initiation may warrant consideration of drug-induced subacute cutaneous lupus erythematosus. Clarifying the time course and potential alternative causes is important for assessing causality.
Source
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Lupus eritematoso cutáneo subagudo pitiriasis rosada-like inducido por omeprazol.
Reviewed by: DrugCard editorial team ·
This article does not replace clinical judgement. Disclaimer
