Bilastine: interactions and reports of QT interval prolongation

The review addresses bilastine for treating allergic rhinitis and urticaria in children and adults. The abstract describes the drug as a non-sedating antihistamine. It states that the article discusses dosing, contraindications and common adverse reactions, including drowsiness and headache. However, the abstract provides no specific doses, age limits for use or list of contraindications.

Interactions. Particular attention is given to potential interactions with P-glycoprotein inhibitors. According to the description, these may increase bilastine plasma concentrations and the risk of adverse reactions. The abstract does not name specific interacting drugs or quantify the increase.

Cardiac safety. Cases of QT interval prolongation associated with bilastine use are mentioned, with an emphasis on caution in patients with a history of arrhythmias. The number of cases, their clinical circumstances, event frequency and causality assessment are not provided. The abstract also provides no separate description of the review’s limitations.